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3 experimental probes had been marshaled with NagA to unveil the supply of the rate limitation for this enzyme. The initial of those experiments compared the premiums of substrate hydrolysis in H2O and D2O. Applying Zn-NagA with N
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The buildings on the compounds tested as substrates for NagA are introduced in Plan six. The substitution of sulfur for oxygen can be employed together with hard and gentle metals to probe the likely for metal-ligand conversation throughout the activation of electrophilic reactions (24, twenty five).
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a worth is somewhat greater for Cd-NagA than for Zn-NagA, as predicted from your inclination of zinc to decrease the p
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